Nie's Lab @PUMC Heart Research

Welcome to our Heart Research Lab led by Prof. Yu Nie!
Here, we focus on pioneering research in cardiac biology and diseases, striving for breakthroughs that can transform heart health care.
Welcome to join us!

Image 1 Image 2 Image 3 Image 4 Image 5 Image 5

News

We are thrilled to announce our groundbreaking research soon to be published in 'Circulation': 'Identifying Cardiomyocyte Ploidy with Nucleus Size'. This pioneering study, co-authored by Dr. Zehao Yao and Dr. Lina Bai, represents a significant leap forward in heart cell biology. By correlating the size of a cardiomyocyte's nucleus with its ploidy, our team offers new insights into cellular mechanisms that may have profound implications for understanding heart health and disease. Stay tuned for the publication of this exhilarating discovery that paints a more intricate picture of the cardiac cellular landscape.


Cardiomyocyte Ploidy Imagery

Research

Heart failure remains one of the leading causes of morbidity and mortality globally, with ischemic heart disease being a major contributor. While mammals possess limited cardiac regeneration shortly after birth, myocardial cells lose their proliferative capacity as they undergo polyploidization thereafter. Given the limited self-repair capacity of the adult mammalian heart post-injury, irreversible loss of functional myocardial cells occurs. Our lab aims to unravel the mysteries of myocardial cell proliferation to achieve cardiac regeneration, investigate the causes and significance of myocardial cell polyploidization, and understand the process of cardiac development, striving for future translation from bench to bedside.

  • Versican, an extracellular matrix component derived from cardiac fibroblasts, is upregulated following neonatal cardiac injury, regulating myocardial cell proliferation. In our recent study, conditional deletion of the Versican (Vcan) gene in cardiac fibroblasts decreased myocardial cell proliferation and impaired neonatal cardiac regeneration. In adult mice, intramyocardial injection of versican post-myocardial infarction enhanced myocardial cell proliferation, reduced fibrosis, and improved cardiac function. Additionally, versican also boosted the proliferation of induced pluripotent stem cell-derived cardiomyocytes. Mechanistically, versican activated integrin β1 and its downstream signaling molecules, including ERK1/2 and Akt, thereby promoting myocardial cell proliferation and cardiac repair.
  • See publication
Heart Regeneration
  • Cardiomyocytes exhibit varying ploidy levels, which undergo developmental changes in physiological conditions and alterations under pathological conditions such as pressure overload and cardiac remodeling. By measuring nuclear volume, we have established a precise tool for assessing ploidy. Leveraging this tool, we aim to delve deeper into unraveling the mysteries of cardiomyocyte nuclear ploidy changes..
  • See publication
Nuclear Ploidy
  • A precise tool named CACCT to identify CHD using micro-CT is developed.
  • See publication
Cardiomyopathy

People

Principal Investigator

Prof. Yu Nie

Prof. Yu Nie

Email: nieyuniverse@126.com

Principal Investigator

Staff

Miaoqing Hu

Miaoqing Hu

staff

Lina Bai

Lina Bai

staff

Postdocs

Ning Liu

Ning Liu

Postdoc Researcher

Xue Bai

Xue Bai

Postdoc Researcher

Yang Cui

Yang Cui

Postdoc Researcher

Ph.D. Students

Ruopu Li

Ruopu Li

Ph.D. student

Dongcheng Cai

Dongcheng Cai

Ph.D. student

He xuan

He Xuan

Ph.D. student

Yifan Xie

Yifan Xie

Ph.D. student

Chenghao Fan

Chenghao Fan

Ph.D. student

liuweijing

Weijing Liu

Ph.D. student

chenying Xiang

Chenying Xiang

Ph.D. student

wenzheng chen

Wenzheng Chen

Ph.D. student

Yixun Li

Yixun Li

Ph.D. student

Yunxiaoxiao Wu

Yunxiaoxiao Wu

Ph.D. student

Hao Wang

Hao Wang

Ph.D. student

Songrui Jia

Songrui Jia

Ph.D. student

Yi Gong

Yi Gong

Ph.D. student

Pen Xiang

Peng Xiang

Ph.D. student

Haocong Mo

Haocong Mo

Ph.D. student

Zheng Qiao

Zheng Qiao

Ph.D. student

M.D. Students

Zehao Yao

Zehao Yao

M.D. student

Yuan Liu

Yuan Liu

M.D. student

Master Students

Shijie Sun

Shijie Sun

Master student

Chiyin Wang

Chiyin Wang

Master student

nan jiang

Nan Jiang

Master student

Haorui Liu

Haorui Liu

Master student

Zhangyuan

Yuan Zhang

Master student

Hangfei Yan

Hangfei Yan

Master student

Tingting Yu

Tingting Yu

Master student

Visiting Scholar

Jianqiu Pei

Jianqiu Pei

Current position: Associate professor at Capital Medical University

Visiting Scholar

Jun Cao

Jun Cao

Current position: Instructor at BJUT

Visiting Scholar

Fei Li

Fei Li

Current position: Cardiovascular Surgery Fellow at Anzhen Hospital

Visiting Scholar

Technician

Xinyu Li

Technician

Yajiao Fan

Technician

Jiacheng Ren

Jiacheng ren

Technician

Zhengkai Wang

Zhengkai Wang

Technician

Lab alumni

Activities

Our lab not only dedicates itself to research but also engages in community activities, including educational workshops and public health talks, alongside fun lab parties!

2024-05-23 Dissertation defense

We are proud to announce that our research group has three new Ph.D. graduates and one master's graduate. Their dedication and hard work have significantly contributed to our field. Congratulations to all on their remarkable achievements!

Lab Activities

2024-04-28 Pre-defense

Exciting news! On 04-28, our lab held the pre-defense for our graduates! Big congratulations to Dr.Ruopu Li, Dr. Dongcheng Cai, Dr. He Xuan and Dr. Shuai Li for their outstanding presentations and hard work!

Lab Activities

2023-09-10 Lab party

Lab Activities

2023-12-24 Cardiac Critical Care Congress in Shanghai

Lab Activities

Selected Publications